28 papers
This cross-sectional study of 7,547 European Phase II–IV clinical trials reveals that while registration data quality on the new CTIS platform is high, sponsor compliance with legal results reporting requirements remains weak, with fewer than half of the trials legally obligated to report doing so within the required timeframe.
This study reveals significant state-by-state disparities in Medicaid coverage for cardiac rehabilitation, highlighting that the lack of standardized reimbursement—particularly in Southern states with high Medicaid enrollment—creates systemic barriers that disproportionately disadvantage vulnerable populations and undermine health equity.
This multilevel analysis of Finland's recent administrative reform reveals that primary health center unit closures were primarily driven by the rationalization of denser existing service networks and the lack of prior collaborative governance structures, while being less likely in municipalities experiencing population growth or having a higher number of private clinics.
This study analyzes national laws in 10 countries against the WHO Global Health and Care Worker Compact, revealing that while many jurisdictions recognize key protections, care workers frequently remain excluded from coverage, with only the United Kingdom fully meeting all four evaluated indicators.
A 2022 cross-sectional study in Tigray, Ethiopia, reveals that despite some positive associations with household disease history and urban residence, the majority of the community exhibits poor knowledge, unfavorable attitudes, and inadequate treatment-seeking and prevention practices regarding cutaneous leishmaniasis, highlighting an urgent need for integrated health education focused on transmission and prevention.
This study of 727 hypertensive patients aged 80 and older reveals that, beyond average blood pressure levels, a reverse-dipper pattern and greater long-term variability in nighttime systolic and daytime diastolic blood pressure are significant independent predictors of increased all-cause mortality.
This qualitative study of rural healthcare systems in southern Minnesota identifies key strengths and significant gaps in integrated palliative care, highlighting the need for improved coordination, funding, and unified networks to enhance access and service delivery for rural populations.
This study demonstrates that while scaling exhaustive OpenStreetMap mapping to achieve household-level health accessibility modeling across Madagascar is feasible, it is highly resource-intensive, requiring an estimated 220 to 350 person-years to generate the granular geospatial data necessary for equitable health system planning.
This study demonstrates that universal opt-out hepatitis C virus testing and treatment upon entry into California state prisons between 2016 and 2023 successfully identified a large number of infections and facilitated equitable access to direct-acting antiviral treatment, particularly for individuals with substance use disorders.
This study evaluates Pakistan's Sehat Sahulat Program to demonstrate that strategic purchasing theory fails in weak governance contexts due to fundamental institutional capacity deficits, leading the authors to propose a four-stage Strategic Purchasing Capacity Stages (SPCS) model to ensure international reforms are aligned with a system's actual governance maturity rather than assuming high-capacity prerequisites.
This study utilizing 2022-2023 BRFSS data reveals that e-cigarette use is independently associated with reduced health-related quality of life and increased unhealthy days among US adults, particularly younger individuals, with these negative effects being amplified when combined with cigarette use and depression.
This target trial emulation study utilizing UK primary care data found that while thiazolidinediones, DPP-4 inhibitors, and sulfonylureas showed similar risks for incident dementia in people with type 2 diabetes, SGLT2 inhibitors were associated with a significantly lower risk of both vascular and all-cause dementia.
This paper summarizes lessons from the HOPE study, which utilized the target trial emulation framework and simulated data to guide the causal analysis of special educational needs provision on health and education outcomes using England's linked administrative data, ultimately recommending the careful specification of causal questions and the use of alternative estimation methods to ensure robust results.
An analysis of 15 years of Canadian women's health research funding reveals a persistent and narrow focus on cancer and pregnancy, leaving critical gaps in the study of other hormonal life stages and diverse populations despite their significant representation in the lifespan.
Using a regression discontinuity design, this study demonstrates that Ontario's OHIP+ pharmacare program significantly reduced unmet mental health care needs and life stress for youth under 25, while the abrupt loss of eligibility at age 25 caused a sharp increase in both barriers to care and psychological strain.
A pragmatic retrospective cohort study of a large multi-specialty practice in Alabama found that implementing structured Chronic Care Management services for Medicare beneficiaries was associated with significant reductions in both total healthcare expenditures and patient out-of-pocket costs compared to eligible non-enrolled patients.
This cross-jurisdictional study of 33 clinical genomic institutions reveals that while most policies permit data sharing without explicit consent for patient care, they frequently lack clear definitions regarding scope, safeguards, and recipient roles, highlighting an urgent need for standardized guidance to ensure responsible and transparent data governance.
This mixed-methods study on Universal Free School Meals in Wales reveals that while children and parents widely support the policy for its social and financial benefits, inconsistent uptake driven by concerns over food quality, portion sizes, and variety necessitates improvements to fully realize its health and equity goals.
This paper introduces Monte Carlo Committee Simulation, a novel neurosymbolic AI system that leverages weighted voting among 14 persona-conditioned large language models to accurately predict both drug reimbursement recommendations and their specific conditions for Canada's Drug Agency, demonstrating high accuracy and calibrated confidence on temporally external validation data.
The paper introduces PRE-CISE, a pre-calibration workflow that integrates coverage, sensitivity, and collinearity analyses to refine prior distributions and calibration targets, thereby streamlining model calibration and enhancing the reliability of health policy models.